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HPV及其相关疫苗的研究进展

Research Progress in HPV and Related Vaccines

【作者】 吴宝杰杨志建

【Author】 WU Baojie;YANG Zhijian;Shanghai Zerun Biotechnology Co.,Ltd.;

【机构】 上海泽润生物科技有限公司

【摘要】 持续性的人乳头瘤病毒(HPV)感染是随后发展为宫颈癌的主要原因。在世界范围内,多种高致癌性HPV正在不断诱发包括宫颈癌在内的多种恶性肿瘤,并维持很高的发病率与病死率。近年来,针对HPV的预防性疫苗和治疗性疫苗的研制开发取得了巨大的进展。通过疫苗预防HPV的感染仍然是目前降低宫颈癌发病率较为经济有效的关键策略。目前,虽然预防性HPV疫苗在全球推广使用并取得显著效果,但仍存在一些不足,而且并无治疗性HPV疫苗上市。多种新型HPV疫苗研究为宫颈癌的进一步防治带来了希望。随着临床调查与研究的深入,低成本且安全有效的新型HPV疫苗备受关注。

【Abstract】 Persistent infection with certain types of human papilloma virus( HPV) is the main cause of subsequent cervical cancer. Different types of HPV constantly induce cervical cancer and associated lesions which may cause high morbidity and mortality all over the world. In recent years,development and trials of HPV vaccines have made great progress.Using the vaccine to prevent HPV infections would be a more cost-effective strategy to reduce the incidence of cervical cancer. At present,prophylactic HPV vaccines have been used widely on a global scale and obtained significant effect,but there are still some shortcomings,and there is no effective therapeutic HPV vaccines for cervical cancer. Many forms of novel HPV vaccines further shed light on prevention and treatment of cervical cancer. With the development of clinical investigation and research,new HPV vaccines which are safe,effective and low cost will draw more attention.

【关键词】 人乳头瘤病毒; 人乳头瘤病毒疫苗; 宫颈癌; 预防性疫苗; 治疗性疫苗;

【Key words】 Human papilloma virus; Human papilloma virus vaccine; Cervical cancer; Prophylactic vaccine; Therapeutic vaccine;

【分类号】R186.9;R737.33;R373.9;

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