CHKD期刊全文数据库

节点文献

阿尔茨海默病发生机制的研究进展

Research progress in the pathogenesis of Alzheimer’s disease

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 张静爽王蓉

【Author】 Zhang Jingshuang;Wang Rong;Department of Central Laboratory,Xuanwu Hospital,Capital Medical University,Beijing Geriatric Medical Research Center,Center of Alzheimer’s Disease,Beijing Institute for Brain Disorders,Key Laboratory for Neurodegenerative Disease of Ministry of Education;

【机构】 首都医科大学宣武医院中心实验室北京市老年病医疗研究中心北京脑重大疾病研究院阿尔茨海默病研究所神经变性病教育部重点实验室

【摘要】 阿尔茨海默病(Alzheimer’s disease,AD),又称老年性痴呆,是一种神经系统退行性疾病,是痴呆中最常见的类型,在老年人中发病率越来越高,临床上主要表现为渐进性记忆减退、认知功能障碍以及其他神经精神症状和行为障碍。阿尔茨海默病的病因尚未明确,发病机制十分复杂,本文就阿尔茨海默病发生机制的研究进展作一简要综述。

【Abstract】 Alzheimer’s disease( AD),also known as senile dementia,is a degenerative disease of the nervous system. It is the most common type of dementia,and its incidence in the elderly is increasing all the time,the major clinical manifestations of AD are progressive memory loss, cognitive dysfunction, and other neuropsychiatric symptoms and behavioral disorders. The etiology of Alzheimer’s disease is not yet clear,and its pathogenesis is complex,this article reviews briefly the past and recent important findings of potential relevance to the pathogenesis of Alzheimer’s disease.

【关键词】 阿尔茨海默病; 发生机制; 淀粉样蛋白; 胰岛素信号传导通路;

【Key words】 Alzheimer’s disease; pathogenesis; amyloid; insulin signaling pathway;

【分类号】R749.16;R-058;R341;

【基金】 国家自然科学基金(30772288);北京市自然科学基金(7132044);首都卫生发展科研专项(首发2011-2001-02)~~

  • 【下载频次】4854
节点文献中: