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鼻咽癌癌变的分子机理

The Molecular Mechanism Involved in The Development of Nasopharyngeal Carcinoma

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【作者】 李桂源刘华英周鸣周后德李小玲

【Author】 LI Gui-Yuan**,***, LIU Hua-Ying**, ZHOU Ming, ZHOU Hou-De, LI Xiao-Ling(Cancer Research Institute, Central South University, Changsha 410078, China)

【机构】 中南大学肿瘤研究所中南大学肿瘤研究所 长沙410078长沙410078

【摘要】 鼻咽癌是一种多基因遗传性肿瘤,在中国南方和国外中国南方移民及后裔中发病率极高,严重危害了我国南方地区人民生命健康.对于这样一种具有明显民族聚集现象和地域差异的恶性肿瘤,目前认为其病理发病机制与遗传和环境因素的共同作用密切相关.现主要阐述鼻咽癌作为一种多基因遗传性肿瘤的病因发病机制,初步建立鼻咽癌易感基因群的概念和鼻咽癌发生发展过程中易感基因群主导的多阶段性多米诺骨牌效应分子机制假说,为寻找鼻咽癌遗传易感风险因子,筛选鼻咽癌高危人群以及探索鼻咽癌靶向性及个体化的诊断和治疗手段奠定实验与理论基础.

【Abstract】 Nasopharyngeal carcinoma (NPC) is a polygenetic inheritance tumor. It has very high incidence in southern China and among immigrants and their offspring from south Chinese, and has done a great harm to the health of south Chinese. As a malignant tumor with obvious tendency of familial aggregation and regional difference, it is suggested that the etiology and pathogenesis of NPC are relevant to the coeffects of genetic and environmental factors. It is the main point to focus on the elucidating of the pathogenesis of PNC as a polygenetic inheritance tumor, primarily establishing of the concept of susceptibility gene groups in NPC and the carcinogenesis model of the multi-step Domino effect involved in the molecular mechanisms of NPC dominated by susceptibility gene groups in order to lay out a substantial foundation for finding the high-risk susceptibility factors of NPC, screening the high-risk population of NPC and exploring the targetic and individual measures in diagnosis and treatment of NPC.

【关键词】 鼻咽癌; 病因发病机制; 易感基因群; 多阶段性多米诺骨牌效应;

【Key words】 nasopharyngeal carcinoma; mechanism of etiology and pathogenesis; susceptibility gene group; multi-step Domino effect;

【分类号】R739.63;R364;R394.2;

【基金】 国家自然科学基金重大项目(30330560);湖南省卫生厅重大专项(05SK1001-1);973重大基础研究前期研究专项(2005CCA03200);国家自然科学基金项目(30300175,30300205,30300063,30400238,30400084,30400528,30500584);湖南省自然科学基金项目(05JJ300063)~~

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