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抗炎性细胞因子与抑郁症

Anti-inflammatory Cytokines and Depression

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【作者】 徐说林文娟

【Author】 XU Yue;LIN Wen-Juan;Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences;University of Chinese Academy of Sciences;

【机构】 中国科学院心理研究所心理健康重点实验室中国科学院大学

【摘要】 细胞因子假说是关于抑郁症发病机理的重要假说,为探讨抑郁症的发病机理和临床治疗方法提供了新方向.细胞因子分为前炎性细胞因子和抗炎性细胞因子.前炎性细胞因子与抑郁症的发病密切相关,而抗炎性细胞因子可能具有抗抑郁的作用.本文着重综述抗炎性细胞因子与抑郁症的关系.抗炎性细胞因子如白介素10、白介素1受体拮抗剂、白介素4、白介素13、转化生长因子β和脂联素等,在抑郁症中表达下降;补充外源抗炎性细胞因子则具有一定的抗抑郁作用.抗炎性细胞因子可通过拮抗前炎性细胞因子的作用,并与MAPK信号通路、神经递质和糖皮质激素相互作用而参与到抑郁症中.抗抑郁药能使抗炎性细胞因子的表达上升,这可能是药物起效的机制之一.抗炎策略在抑郁症的治疗中有重要应用前景.

【Abstract】 In recent years, the cytokine hypothesis of depression has received considerable research attention,providing insights on the mechanism study and the therapeutic treatment of depressive disorders. Two classes of cytokines, pro-inflammatory cytokines and anti-inflammatory cytokines, are proven to be associated with depression. In this review, the focus is on the research of anti-inflammatory cytokines, which are believed to have a key role in alleviating depression-related symptoms. Anti-inflammatory cytokines, such as interleukin-10,interleukin-1 receptor antagonist, interleukin-4, interleukin-13, transforming growth factor-β, and adiponectin,show decreased concentrations during depressive episodes. Anti-inflammatory cytokines participate in the regulation mechanism of depression through antagonizing pro-inflammatory cytokines and interacting with MAPK signaling, neurotransmitters, and glucocorticoids. Various kinds of antidepressants can lead to an increased secretion of anti-inflammatory cytokines, which might be the action mechanism of antidepressants. Overall,accumulating evidences from the literature demonstrate positive prospects of using anti-inflammatory cytokines as a therapeutic alternative to treat depression.

【关键词】 抑郁症; 细胞因子; 抗炎性细胞因子; 抗炎作用; 抗抑郁药;

【Key words】 depression; cytokines; anti-inflammatory cytokines; anti-inflammation; antidepressant;

【分类号】R749.42;R392.114;R971.43;

【基金】 国家自然科学基金(30770718,31170987);中国科学院知识创新工程(KSCX2-EW-J-8)资助项目~~

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