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卒中后抑郁状态的发生率及相关因素研究

Incidence and relative factors in post-stroke depression

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【作者】 龙洁刘永珍蔡焯基柴滨陆菁菁贺佳丽任艳萍

【Author】 LONG Jie*, LIU Yongzhen,CAI Zhuoji, et al. *Department of Neurology, Capital University of Medical Sciences Affiliated Tiantan Hospital,Beijing 100050,China

【机构】 首都医科大学附属天坛医院神经内科北京安定医院

【摘要】 目的 了解卒中后抑郁状态 (PSD)的发生率及其相关因素。方法 采用Hamilton抑郁量表和自制一般情况调查表 ,对 5 2 0例脑卒中患者进行调查评分 ,并用逐步Logistic回归统计方法对各相关因素进行分析。结果 PSD总发生率为 34 2 % ,其中轻度 2 0 2 % ,中度 10 4% ,重度 3 7%。对PSD影响最大的相关因素是既往抑郁症史 ,其次是性别、家庭和睦情况、合并疾病种类、神经功能缺损严重程度和卒中后病程。结论 上述因素是本组PSD患者的主要预测因素 ,为预防PSD提供参考依据。

【Abstract】 Objective To investigate the incidence and relative factors of post-stroke depression (PSD). Methods 520 patients with stroke were assessed by 17-item Hamilton Depression Rating Scales (HAMD). A self-designed register form was analysed in 520 stroke survivorsA multiple factor analysis with the logistic regression method was carried out on the basis of these data. Results Among them, 178 cases (34.2%) were identified as depression. The minor, moderate and major incedenses were 20.2%, 10.4% and 3.7% respectively. In addition, stepwise regression analysis shows that important risk factors involved in PSD contained depression history, sex, family harmony, accompanying disease, neurological deficit and stoke course. Conclusion The factors above were the major predictive factors and useful for PSD prevention

【关键词】 脑血管意外; 抑郁症; Logistic模型;

【Key words】 Cerebrovascular disorders; Depression; Logistic models;

【分类号】R749.42;R195.1;R743.3;

【基金】 北京市科学技术委员会资助课题 (95 3 3 0 40 0 5 )

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