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2016中国帕金森病诊断标准解读

Introduction of clinical diagnostic criteria for Parkinson disease in China(2016)

【作者】 陈永平商慧芳

【Author】 CHEN Yong-ping;SHANG Hui-fang;Department of Neurology,West China Hospital,Sichuan University;

【机构】 四川大学华西医院神经内科

【摘要】 在英国脑库帕金森病临床诊断标准的基础上,《2016中国帕金森病诊断标准》是参考了2015年国际运动障病学会(MDS)推出的帕金森病临床诊断新标准,结合国情,对中国2006年版的帕金森病诊断标准进行了更新。为了达到早期诊断的目的,帕金森综合征的核心症状去掉了姿势平衡障碍;新的诊断标准分成临床确诊和临床很可能帕金森病2个层级,精简了支持标准为4项,增加了辅助检查和非运动症状作为支持标准之一;增加了警示项,缺乏非运动症状也作为一项警示标准。

【Abstract】 The new revision of Clinical Diagnostic Criteria for Parkinson’s Disease in China(2016) which was based on the UK PD society brain bank clinical diagnostic criteria and referenced the 2015 MDS-PD clinical diagnostic criteria, updated some content of Clinical Diagnostic Criteria for Parkinson’s Disease in China(2006). The new criteria included two distinct levels of diagnostic certainty: clinically established PD and clinically probable PD. In order to early diagnose PD, the item "postural instability"was not included in the core features of Parkinsonism. The ancillary diagnostic test such as metaiodobenzylguanidine scintigraphy clearly documenting cardiac sympathetic denervation or hyperechogenicity of substantial nigria(>20 mm2) detected by transcranial sonography and nonmotor manifestation of olfactory loss or hyposmia was added as as one item of the supportive criteria in the new criteria. Previous eight items of supportive criteria were simplified to four items. Auxilliary examination and non-motor manifestations were included as one of supportive criteria. Ten items of red flag were added in the new criteria. Lack of common non-motor manifestations was defined as one item of red flag.

【关键词】 帕金森病; 诊断标准;

【Key words】 Parkinson disease; diagnostic criteria;

【分类号】R742.5;R-05;R441;

【基金】 国家自然科学基金面上项目(85171247)

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