CHKD期刊全文数据库

节点文献

利培酮治疗精神分裂症的开放性临床验证

An open trial of risperidone in the treatment of schizophrenia

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 于欣侯也之舒良王秀玲李冰刘卫红林凯杨顺才宋丽华廖安燕谢家康贾宏晓张继志

【Author】 Yu Xin * , Hou Yezhi, Shu Liang, et al. * Institute of Mental Health, Beijing Medical University, Beijing 100083

【机构】 北京医科大学精神卫生研究所首都医科大学北京安定医院

【摘要】 为验证利培酮治疗精神分裂症的有效性及安全性,对60例精神分裂症住院患者予利培酮1~10mg/d治疗,疗程为8周。以简明精神病评定量表评定疗效,以不良反应症状量表评定药物不良反应。结果显示,治疗结束时显效率(痊愈+显著好转)为64%,有效率88%。利培酮治疗的起效时间为2周,有效治疗日剂量范围在5.0~6.5mg。较多见的不良反应为头晕、困倦等。提示利培酮对精神分裂症的阳性症状及阴性症状均有较好的疗效。

【Abstract】 The purpose of the study was to investigate the safety and efficacy of risperidone in the treatment of schizophrenic patients in a 8-week, open trial. Sixty patients in the study met the diagnostic criteria for schizophrenia described in the 10th edition of International Classification of Diseases (ICD-10) and the 4th edition of Diagnostic and Statistical Manual of Mentual Disorder (DSM-Ⅳ). The dosage of risperidone ranged 1~10 mg/d. The brief psychiatric rating scale (BPRS) was used for the efficacy and Treatment Emergent Sympton Scale (TESS) for unwanted effects. At the end of the study, 64% of the patients were rated as marked improvement and 88% of them as improvement. The clinical effectiveness of risperidone showed up at the end of the second week of treatment, the optimal dose ranged from 5.0 to 6.5 mg/d. The common side effects of risperidone were dizziness and drowsiness. The result suggested that risperidone is effective in the treatment of positive and negative symptons of schizophrenia.

【关键词】 精神分裂症; 利培酮;

【Key words】 Schizophrenia Risperidone;

【分类号】R749.3;R971.4;R45;

  • 【下载频次】484
节点文献中: