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抗菌药物不良反应的社会与经济后果调查

An Investigation into Socio-economic Impact of Adverse Drug Reactions of Antibacterial Agent Irrational Use

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【作者】 肖永红侯芳王进颜青孙自镛吕晓菊杨莉郑迎东

【Author】 XIAO Yong-hong, HOU Fang, WANG Jin, et al. Institute of Clinical Pharmacology, First Hospital, Peking University, Beijing, 100191, China

【机构】 北京大学第一医院临床药理研究所中国医院协会药事管理专业委员会华中科技大学同济医院四川大学华西医院北京大学公共卫生学院

【摘要】 目的:研究抗菌药物不良反应所造成的社会经济负担。方法:应用文献检索与现场调查相结合的方式,对我国抗菌药物不良反应进行调查。结果:我国抗菌药物使用以及不良反应的发生占所有药品的1/3以上,抗菌药物综合不良反应发生率为10.0%~20.0%;我国每年因抗菌药物不良反应需要住院或延长住院时间的患者为55.0万~263.4万人次,门诊中重度抗菌药物不良反应发生为1473.8万人次,抗菌药物不良反应导致约15.0万人死亡;每年用于抗菌药物不良反应处理费用为29.1亿~139.3亿元,导致社会生产力损失3.4亿~16.2亿元。结论:抗菌药物不良反应占我国药物不良反应比例高,所致后果严重,大部分与不合理用药有关,提倡合理使用抗菌药物具有重要社会经济意义。

【Abstract】 Objective: To investigate the socio-economic impact of drug adverse reactions (ADR) coursed by antibacterial agents. Methods: By the on-site investigation and literature analysis, the socio-economic impact of antibacterial ADR was evaluated. Results: ADRs of antibacterial agents took 1/3 of all the drugs ADR in China, which occurred in 10.00%~20.00% patients with antibacterial therapy. It was estimated that, yearly in China, 550 000~2 634 000 person-times should admit hospital or prolong hospital stay-time for antibacterial agent ADRs. 14 738 000 person-times suffered from moderate to severe antibacterial agent ADRs in outpatient setting, and 150 000 patients died of antibacterial agent ADRs. The antibacterial agent ADRs treatment cost 2.91~13.93 billion RMB yuan and led social productivity loss about 340 million~1.62 billion RMB yuan. Conclusions: ADR coursed by antibacterial agents is a crucial public health problem, and most of the ADR associates with drug irrational use. Campaign for antibacterial agent rational use is an urgent need in China.

【关键词】 抗菌药物; 药物不良反应; 社会经济影响;

【Key words】 antibacterial agents; adverse drug reactions; socio-economic impact;

【分类号】R994.11;R-054;R978.1;

【基金】 中国科学技术协会重大政策研究课题(2006ZCYJ02)

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