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骨髓间充质干细胞治疗溃疡性结肠炎研究进展

Review on Treatment of UC by Using BMSCs

【作者】 崔国宁刘喜平

【Author】 CUI Guoning;LIU Xiping;Gansu Medical University of Traditional Chinese Medicine;

【机构】 甘肃中医药大学

【摘要】 溃疡性结肠炎(UC)是一种免疫性疾病,其病情易于反复,迁延难愈。骨髓间充质干细胞是一种具有多向分化潜能的细胞,研究发现在溃疡性结肠炎的过程中,通过体外移植骨髓间充质干细胞,其能够分化、迁移、定植到损伤的结肠黏膜表面,促进结肠黏膜组织的修复与重建。近几年来应用骨髓间充质干细胞在治疗溃疡性结肠炎方面的研究,包括应用骨髓间充质干细胞,或者骨髓间充质干细胞联合其他方法治疗溃疡性结肠炎,或者联合中药提取物治疗溃疡性结肠炎等相关方面,希望对应用骨髓间充质干细胞治疗溃疡性结肠炎有一个全新的认识。

【Abstract】 The ulcerative colitis is an immune disease,which is easy to relapse and deferment painless. The BMSCs have the function of multi-directional potential cells. The study found that through the transplantation of BMSCs into the vitro on the process of UC,it can divide,migrate,engraft the surface of colonic mucosa,promoting the colonic mucosa’s rehabilitation and reconstruction. This paper reviews the study of the treatment of UC by BMSCs in recent years,including the treatment of BMSCs,the treatment of BMSCs combined with others methods or herbal extracts and so on,hoping to have a new understanding of the treatment of UC by BMSCs.

【关键词】 溃疡性结肠炎(UC); 骨髓间充质干细胞(BMSCs); 综述;

【Key words】 ulcerative colitis(UC); bone marrow mesenchymal stem cells(BMSCs); review;

【分类号】R329.24;R574.621;R45;

【基金】 国家自然科学基金项目(81560747)

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