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肝纤维化发病机制与临床诊断的研究进展

Liver fibrosis: pathogenesis and clinical diagnosis

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【作者】 邵祥强肖华胜

【Author】 Xiang-Qiang Shao, Center for Functional Genomics, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China Hua-Sheng Xiao, Center for Functional Genomics, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China Hua-Sheng Xiao, National Engineering Center for Biochip at Shanghai, Shanghai 201203, China

【机构】 中国科学院上海生命科学研究院系统生物学重点实验室功能基因组中国科学研究生院生物芯片上海国家工程研究中心

【摘要】 肝纤维化是机体对各种病因引起的慢性肝损伤后的一种损伤修复反应,慢性肝病发展至最后将发展成为肝硬化,肝硬化及其并发症威胁着全球居民的生命健康.在过去的几十年中,人们在肝纤维化的发生机制方面已经取得了很大的进展.HSC的激活是肝纤维化发生过程中的一个重要事件,同时各类细胞因子与其对应受体;以及各类炎症细胞均在纤维化发展过程中扮演着重要的角色.在肝纤维化的诊断领域,除了传统的肝活检技术,新型分子标志物以及影像学诊断技术均为临床诊断提供了准确的诊断依据.肝纤维化发生机制与诊断技术领域所取得的重大发现,给慢性肝病患者的纤维化治疗以及康复带来了新的曙光.

【Abstract】 Hepatic fibrosis represents a wound healing response to liver injury due to various causes. Cirrhosis is the most advanced stage of fibrosis and, along with its complications, constitutes one of the major causes of morbidity and mortality worldwide. Past decades have witnessed tremendous progress in understanding the mechanisms of hepatic fibrosis. Activation of hepatic stellate cells is a key event in fibrosis, while a wide range of cytokines and their receptors and inflammatory cell subsets participate in the dynamic regulation of fibrosis progression. In terms of the diagnosis of hepatic fibrosis, novel serum markers and transient elastography have helped a lot in the assessment of liver fibrosis in addition to traditional liver biopsy. These findings both in the mechanism of liver fibrosis and the diagnosis of fibrosis are important for the implementation of rationally based approaches to limit fibrosis, accelerate repair and enhance liver regeneration in patients with chronic liver disease.

【关键词】 肝纤维化; 肝星状细胞; 纤维化发生; 诊断; 肝活检; 血清学标志物;

【Key words】 Liver fibrosis; Hepatic stellate cells; Fibrogenesis; Diagnosis; Liver biopsy; Serum biomarker;

【分类号】R256.49;R445;R364.2;

【基金】 国家高技术研究发展计划(863)基金资助项目,No.2006AA02A411~~

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