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代谢组学在中医药领域应用现状

Application of Metabonomics in TCM Research

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【作者】 杨延泽邓毅杨秀娟杨志军吴国霞曼琼

【Author】 YANG Yan-ze;DENG Yi;YANG Xiu-juan;YANG Zhi-jun;WU Guo-xia;MAN Qiong;Gansu University of Chinese Medicine;Provincial Key Laboratory of Medicinal Chemistry and Quality Research in Gansu Province;

【机构】 甘肃中医药大学甘肃省高校中(藏)药化学与质量研究省级重点实验室

【摘要】 代谢组学是一门通过研究生物体代谢网络和整体内在代谢变化的组学,以此阐释药物作用机理及疾病发病机制,与中医学整体观有一定相似性。代谢组学技术有利于推动中医药现代化进程。本文阐述代谢组学的概念及其近年来在中医证候、中药质量及成分、中药复方等方面的应用研究,探讨目前研究存在的问题及前景。

【Abstract】 Metabolomics is an omics subject which studies on the metabolic network of organism and the intrinsic metabolic change of entirety with the aim of clarifying the mechanism of medicinal effect and pathogenesis of disease, is similar to the whole concept theory of Chinese medicine. The mectabolomics technology helps to promote the modern process of traditional Chinese medicine. This article illustrated the application research on the concept of metabolomics, the syndrome of Chinese medicine, quality and components of traditional Chinese medicine, traditional Chinese medicine compounds and so on, explored the problems on the current research and the prospect meanwhile.

【关键词】 代谢组学; 中医证候; 中药; 复方; 综述;

【Key words】 metabonomics; syndrome of Chinese medicine; traditional Chinese medicine; compound prescription;

【分类号】R333.6;R241.301;R203.12;

【基金】 国家自然科学基金地区基金(81360633);甘肃省自然科学基金(1506RJZA044);甘肃省中医药管理局项目(1606JZA044);甘肃省高校中(藏)药化学与质量研究省级重点实验室开放课题(zzy-2016-06)

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