ZYCA200101017CHKJ9902石菖蒲对行为绝望动物抑郁模型的抗抑郁作用Antidepressant Effect of Water Decoction of Rhizoma Acori Tatarinowii in the Behavioural Despair Animal Models of Depression李明亚陈红梅Li Mingya, Chen Hongmei (Guangdong College of pharmacy,Guangzhou 510224)广东药学院药理教研室广东药学院药理教研室 广州 510224广州 510224目的:对石菖蒲水煎剂的抗抑郁作用进行筛选研究。方法:用小鼠尾悬挂试验和大鼠强迫游泳试验抑郁模型对石菖蒲水煎剂的抗抑郁作用进行研究。结果:在小鼠尾悬挂试验和大鼠强迫游泳试验中,石菖蒲水煎剂与氟西汀一样可以使小鼠尾悬挂的失望时间和大鼠强迫游泳的不动时间显著缩短,并呈一定的剂量依赖性,但其药理作用比氟西汀弱。石菖蒲的各剂量组与生理盐水对照组比较,统计学上有非常显著性差异。结论:石菖蒲水煎剂在行为绝望动物抑郁模型上有明显抗抑郁作用。Object:To assess the antidepressant effect of the water decoction of Rhizoma acori tatarinowii. Methods: By using the rat forced swimming test and mouse tail suispension test models of depression, the antidepressant effect of Rhizoma acori tatarinowii was observed. Results: The water decoction of Rhizoma acori tatarinowii and Fluoxetine significantly shortened motionless time of rat forced swimming and despair time of mouse tail suspension in the two behavioural despair animal models of depression. Antidepressant effect of water decoction of Rhizoma a-cori tatarinowii showed dose-dependence in the certain degree.The effect of water decoction of Rhizoma acori tatarinowii was weaker than that of Fluoxetine.There was a significant difference between every dose group of Rhizoma acori tatarinowii and saline control group. Conclusion: The water decoction of Rhizoma acori tatarinowii possessed obviously antidepressant effect in the behavioural despair animal models of depression.石菖蒲水煎剂抗抑郁作用Rhizoma acori tatarinowiiWater decoctionAntidepressant effect中药材Journal of Chinese Medicinal Materials200101R285R282.714;R283.635;R-332;抗抑郁作用:8448;动物模型:1718;水煎剂:371;筛选研究:299;药理作用:184;空白对照组:160;大鼠:159;定志小丸:47;细辛醚:47;中枢神经递质:35;E799MEDI01S3ZYCA06841635;06845875;0062483;0062483;ZYCA2001-01-15240中文;E057;2636179;4953610;2685855;3790851;5222686;4285545;R749.42;R-055;R749.75;R852.22;R971.4;R961;R944.1;8102334;4756562;5418821;抗抑郁作用;石菖蒲;水煎剂;抑郁;动物;行为;模型;强迫游泳;尾悬;试验;氟西汀;小鼠;大鼠;筛选;药理作用;依赖性;显著性差异;生理盐水;时间;对照组;Acorus Tatarinowii;Depressions;Animal;animal;Behavior;Fluoxetine;Mice;Rats;Pharmacologic Actions;normal saline;physiological saline;Time;Control Groups;0.2009YCNKI:SUN:ZYCA.0.2001-01-017chkj2001E057_6;